The series of inter-Disciplinary Underground Science and Technology (i-DUST) conferences started in 2004 with the name "Small and Medium Scale Underground Science International Conference" in order to disseminate and promote the scientific research performed around the activities of the Low-Noise Underground Laboratory (LSBB) of Rustrel, Pays d'Apt, in France.

Since then, i-DUST conferences became a regular opportunity to promote and discuss small- and medium-scale underground interdisciplinary scientific research that require low-noise characterization and modelling of terrestrial, atmospheric and near-Universe environments. They are a place to share knowledge and know-how, discuss new ideas and promote new collaborative and innovative projects at an international level.